Why it matters: In line with the LESS™ Society’s TIER & REP philosophies—Training, Innovation, Education, Research and Restore motion, Early intervention, Preserve anatomy—NanoFUSE™ represents a next-gen approach to promoting spinal fusion with less surgical impact.

What it is: NanoFUSE™ combines demineralized bone matrix (DBM) with 45S5 nano-bioactive glass in an FDA-cleared formulation designed to create a robust osteoconductive and osteoinductive environment for bone regeneration.

Key advantages

• Optimized healing: Osteopromotive DBM + bioactive glass ions support new bone formation throughout the defect—not just at the margins.

• Workflow friendly: Ready-to-use handling can reduce OR time and streamline LESS procedures.

• Patient-centered outcomes: Aims for faster recovery, less tissue disruption, and durable fusion results—consistent with LESS techniques.

• System value: Potential for fewer complications and shorter stays, improving overall efficiency.

Who benefits

• Surgeons: Strong biologic profile with straightforward use.

• Patients: Less invasive solutions and quicker return to activity.

• Health systems: Cost-effective care through efficient healing.

Read the full feature by Sukanya Chebrolu, MS, and Chukwunonso C. Ilogu, MD, MS on our blog. This content is educational and not medical advice.